Endocrine Abstracts

Objective: Assess the effectiveness of complex treatment of obesity with the use of orlistat (intestinal lipase inhibitor) on the knee OA (KOA) and the dynamics of cytokines (CRP, IL-6, TNF-α) depending on the degree of weight loss.Methods: 50 female patients (45–65 y.o.) with Kellgren-Lawrence stage II-III KOA and obesity (BMI > 30 kg/m²). Patients in Group 1 (n = 25) took 120 mg of orlistat 3 times a day in co...